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A random Abstract
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Monosomy 21 in two patients with acute nonlymphocytic leukemia.
[monosomy 21]
Among
50
cases
of
acute
nonlymphocytic
leukemia
(
ANLL
)
with
available
cytogenetic
data
seen
in
our
section
since
May
1988
,
two
were
found
to
carry
a
monosomy
21
abnormality
which
has
been
rarely
reported
in
hematologic
malignancies
.
The
first
case
is
a
58
-
year
-old
male
with
a
diagnosis
of
AML
,
FAB
M
2
,
who
died
of
refractory
leukemia
9
months
later
.
The
other
case
is
a
59
-
year
-old
female
with
AML
,
FAB
M
2
.
Complete
remission
was
achieved
initially
but
she
died
of
sepsis
3
months
later
with
no
evidence
of
leukemic
relapse
.
Monosomy
21
is
not
yet
recognized
as
a
nonrandom
cytogenetic
abnormality
in
ANLL
,
whereas
its
unusual
predilection
in
AML
,
especially
the
FAB
M
2
or
M
4
categories
,
as
noted
in
our
study
and
others
'
reports
,
have
raised
this
possibility
.
Further
studies
and
the
accumulation
of
new
cases
are
needed
in
the
hope
of
defining
it
as
a
subtype
of
ANLL
.
Diseases
Validation
Diseases presenting
"available cytogenetic data"
symptom
monosomy 21
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