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Cytogenetic studies in de novo acute nonlymphocytic leukemia.
[monosomy 21]
There
is
currently
considerable
interest
in
the
cytogenetic
analysis
of
leukemia
.
The
improvement
of
banding
techniques
has
made
it
possible
to
rather
precisely
identify
deletion
,
translocation
,
inversions
,
and
other
structural
chromosome
abnormalities
.
Specific
recurring
chromosome
abnormalities
associated
with
distinctive
morphologic
features
are
thus
increasingly
recognized
in
acute
nonlymphocytic
leukemia
.
For
example
,
uneven
geographic
distribution
of
nonrandom
specific
chromosome
aberrations
has
been
reported
.
We
herein
report
the
results
of
chromosome
studies
on
30
Chinese
patients
with
de
novo
acute
nonlymphocytic
leukemia
.
Cytogenetic
studies
were
performed
at
Veterans
General
Hospital
-
Taipei
,
from
1988
to
1993
,
on
unselected
samples
of
30
patients
with
de
novo
acute
nonlymphocytic
leukemia
.
Chromosome
analysis
was
performed
by
short
-term
culture
techniques
on
bone
marrow
material
obtained
from
patients
at
diagnosis
.
Metaphase
chromosomes
were
banded
by
the
conventional
trypsin-
Giemsa
banding
technique
and
then
karyotyped
according
to
the
International
System
for
Human
Cytogenetic
Nomenclature
(
ISCN
)
.
Classification
of
leukemia
was
based
on
the
criteria
of
the
French
-
American
-
British
cooperative
group
.
Of
the
30
patients
with
adequate
specimens
,
17
(
56
%
)
demonstrated
clonal
chromosome
abnormalities
.
Six
patients
were
found
to
have
structural
rearrangements
and
seven
patients
have
a
numerical
change
as
the
sole
abnormality
.
Four
patients
showed
both
structural
and
numerical
anomalies
.
t
(
8
;
21
)
was
found
in
1
of
the
8
M
2
type
ANLL
patients
and
two
of
them
had
monosomy
21
.
Four
of
the
6
patients
with
acute
promyelocytic
leukemia
(
APL
;
M
3
subtype
)
showed
t
(
15
;
17
)
.
Two
patients
with
M
4
type
leukemia
and
abnormal
bone
marrow
eosinophils
showed
inv
(
16
)
(
p
13
q
22
)
.
One
patient
with
M
4
type
leukemia
demonstrated
the
loss
of
chromosome
#
7
and
none
showed
the
loss
or
deletion
of
chromosome
#
5
.
T
his
study
revealed
a
consistent
finding
of
t
(
15
;
17
)
in
APL
;
however
,
a
low
incidence
of
t
(
8
;
21
)
,
-
5
/
5
q-
and
-
7
/
7
q-
in
our
patients
demonstrated
the
possible
difference
in
the
incidence
of
chromosomal
abnormalities
in
ANLL
between
the
oriental
peoples
and
the
whites
.