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Double trisomy in spontaneous abortions.
[monosomy 21]
Cytogenetic
data
on
products
of
conception
from
spontaneous
abortions
studied
over
a
10
-
year
period
have
been
reviewed
for
double
trisomies
.
A
total
of
3034
spontaneous
abortions
were
karyotyped
between
1986
and
1997
.
Twenty
-
two
cases
with
double
trisomy
,
one
case
with
triple
trisomy
,
and
a
case
with
a
trisomy
and
monosomy
were
found
.
The
tissues
studied
were
mostly
sac
,
villi
,
or
placenta
.
The
gestational
age
ranged
from
6
to
11
weeks
and
the
mean
age
was
8
.
2
+
/
-
1
.
7
(
SD
)
weeks
.
The
mean
maternal
age
in
years
was
35
.
9
+
/
-
5
.
3
.
Of
the
twenty-
two
cases
,
four
were
mosaics
.
All
but
two
of
the
cases
involved
autosomal
aneuploidies
.
The
double
trisomies
included
chromosomes
2
,
4
,
5
,
7
,
8
,
12
,
13
,
14
,
15
,
16
,
17
,
18
,
20
,
21
,
and
22
.
The
chromosomes
that
were
trisomic
in
more
than
one
double
trisomy
case
were
numbers
16
(
8
cases
)
,
8
(
5
cases
)
,
15
(
4
cases
)
,
2
,
13
,
and
21
(
3
cases
each
)
,
and
5
,
7
,
14
,
18
,
20
,
22
,
and
X
(
2
cases
)
.
The
triple
trisomy
involved
chromosomes
18
,
21
,
and
X
.
The
monosomy
and
trisomy
case
was
a
mosaic
,
with
a
monosomy
21
in
all
cells
and
some
cells
also
with
a
trisomy
5
.
The
double
trisomies
cited
for
the
first
time
in
this
study
were
4
/
13
,
5
/
16
,
8
/
14
,
8
/
15
,
14
/
21
,
15
/
20
,
and
7
/
12
.
The
pooled
mean
maternal
age
for
double
trisomy
cases
(
34
.
1
+
/
-
5
.
7
years
)
was
higher
than
that
for
single
trisomy
cases
(
31
+
/
-
6
.
1
years
)
.
The
difference
was
statistically
significant
at
P
=
<
0
.
001
.
The
pooled
mean
gestational
age
of
spontaneous
abortions
was
lower
for
double
trisomy
(
8
.
7
+
/
-
2
.
2
weeks
)
than
for
reported
single
trisomy
cases
(
10
.
1
+
/
-
2
.
9
weeks
)
.
This
difference
is
also
statistically
significant
at
P
=
<
0
.
001
.
The
sex
ratio
among
double
trisomies
was
15
females
to
13
males
.
This
difference
was
not
statistically
significant
from
the
expected
1
:
1
.
Diseases
Validation
Diseases presenting
"single trisomy cases"
symptom
monosomy 21
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