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Translocation (11;14)(q13;q32) and preferential involvement of chromosomes 1, 2, 9, 13, and 17 in mantle cell lymphoma.
[monosomy 21]
We
have
studied
13
cases
of
histologically
confirmed
mantle
cell
lymphomas
(
MCL
)
combining
cytological-immunological
features
with
conventional
cytogenetics
and
in
situ
hybridization
(
ISH
)
techniques
.
Peripheral
blood
smears
and
lymph
node
biopsies
expressed
the
typical
mantle
zone
pattern
with
alpha
B-
cell
phenotype
.
Most
of
the
cases
(
11
of
13
)
had
lymphomatous
cells
in
the
peripheral
blood
.
Chromosome
analysis
was
carried
out
on
lymphoid
cells
from
peripheral
blood
and
/
or
lymph
node
biopsies
.
Phytohemagglutinin
(
PHA
)
and
phorbol
12
-
myristate
13
acetate
(
TPA
)
were
used
as
mitogens
.
Biotin-labeled
libraries
of
whole
chromosomes
implicated
in
complex
karyotypes
were
used
to
improve
their
interpretation
.
Clonal
chromosome
abnormalities
were
found
in
10
of
13
patients
(
77
%
)
;
7
of
these
had
a
complex
abnormality
.
The
most
frequent
recurrent
structural
abnormalities
were
:
t
(
11
;
14
)
(
q
13
;
q
32
)
,
involvement
of
chromosome
1
(
der
[
1
]
,
del
[
1
]
,
dup
[
1
]
)
,
chromosome
2
(
del
[
2
]
,
der
[
2
]
)
,
chromosome
9
(
der
[
9
]
,
-
9
)
,
chromosome
13
(
add
[
13
]
,
t
[
13
q
]
)
,
and
chromosome
17
(
add
[
17
]
,
der
[
17
]
,
t
[
17
q
]
)
.
The
most
frequent
numerical
abnormalities
were
monosomy
21
and
loss
of
the
Y
chromosome
.
Diseases
Validation
Diseases presenting
"peripheral blood"
symptom
adrenomyeloneuropathy
allergic bronchopulmonary aspergillosis
aniridia
cohen syndrome
congenital toxoplasmosis
cutaneous mastocytosis
erdheim-chester disease
esophageal adenocarcinoma
esophageal squamous cell carcinoma
familial mediterranean fever
gm1 gangliosidosis
junctional epidermolysis bullosa
lamellar ichthyosis
monosomy 21
oligodontia
omenn syndrome
scrub typhus
severe combined immunodeficiency
typhoid
von hippel-lindau disease
waldenström macroglobulinemia
wiskott-aldrich syndrome
wolf-hirschhorn syndrome
x-linked adrenoleukodystrophy
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