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Translocation (11;14)(q13;q32) and preferential involvement of chromosomes 1, 2, 9, 13, and 17 in mantle cell lymphoma.
[monosomy 21]
We
have
studied
13
cases
of
histologically
confirmed
mantle
cell
lymphomas
(
MCL
)
combining
cytological-immunological
features
with
conventional
cytogenetics
and
in
situ
hybridization
(
ISH
)
techniques
.
Peripheral
blood
smears
and
lymph
node
biopsies
expressed
the
typical
mantle
zone
pattern
with
alpha
B-
cell
phenotype
.
Most
of
the
cases
(
11
of
13
)
had
lymphomatous
cells
in
the
peripheral
blood
.
Chromosome
analysis
was
carried
out
on
lymphoid
cells
from
peripheral
blood
and
/
or
lymph
node
biopsies
.
Phytohemagglutinin
(
PHA
)
and
phorbol
12
-
myristate
13
acetate
(
TPA
)
were
used
as
mitogens
.
Biotin-labeled
libraries
of
whole
chromosomes
implicated
in
complex
karyotypes
were
used
to
improve
their
interpretation
.
Clonal
chromosome
abnormalities
were
found
in
10
of
13
patients
(
77
%
)
;
7
of
these
had
a
complex
abnormality
.
The
most
frequent
recurrent
structural
abnormalities
were
:
t
(
11
;
14
)
(
q
13
;
q
32
)
,
involvement
of
chromosome
1
(
der
[
1
]
,
del
[
1
]
,
dup
[
1
]
)
,
chromosome
2
(
del
[
2
]
,
der
[
2
]
)
,
chromosome
9
(
der
[
9
]
,
-
9
)
,
chromosome
13
(
add
[
13
]
,
t
[
13
q
]
)
,
and
chromosome
17
(
add
[
17
]
,
der
[
17
]
,
t
[
17
q
]
)
.
The
most
frequent
numerical
abnormalities
were
monosomy
21
and
loss
of
the
Y
chromosome
.
Diseases
Validation
Diseases presenting
"lymph node biopsies expressed the typical mantle zone pattern with alpha b-cell phenotype"
symptom
monosomy 21
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