Rare Diseases Symptoms Automatic Extraction
Home
A random Abstract
Our Project
Our Team
The basidiomycetous yeast Trichosporon may cause severe lung exacerbation in cystic fibrosis patients - clinical analysis of Trichosporon positive patients in a Munich cohort.
[allergic bronchopulmonary aspergillosis]
The
relevance
of
Trichosporon
species
for
cystic
fibrosis
(
CF
)
patients
has
not
yet
been
extensively
investigated
.
The
clinical
course
of
CF
patients
with
Trichosporon
spp
.
in
their
respiratory
secretions
was
analysed
between
2003
and
2010
in
the
Munich
CF
center
.
All
respiratory
samples
of
360
CF
patients
(
0
-
52
.
4
years
;
mean
FEV
1
2010
81
.
4
%
pred
)
were
investigated
.
In
8
patients
(
2
.
2
%
,
3
male
,
mean
age
21
.
8
years
)
Trichosporon
was
detected
at
least
once
.
One
patient
carried
T
.
asahii
.
One
patient
carried
T
.
mycotoxinivorans
and
one
patient
T
.
inkin
as
determined
by
DNA
sequencing
.
As
potential
risk
factors
for
Trichosporon
colonization
steroid
treatment
,
allergic
bronchopulmonary
aspergillosis
(
ABPA
)
and
CF
associated
diabetes
were
identified
in
6
,
5
,
and
2
patients
respectively
.
For
one
patient
,
the
observation
period
was
not
long
enough
to
determine
the
clinical
course
.
One
patient
had
only
a
single
positive
specimen
and
exhibited
a
stable
clinical
course
determined
by
change
in
forced
expiratory
volume
in
one
second
(
FEV
1
)
,
body-mass-index
(
BMI
)
,
C-
reactive
protein
(
CRP
)
and
immunoglobulin
G
(
IgG
)
.
Of
6
patients
with
repeatedly
positive
specimen
(
mean
detection
period
4
.
5
years
)
,
4
patients
had
a
greater
decline
in
FEV
1
than
expected
,
2
of
these
a
decline
in
BMI
and
1
an
increase
in
IgG
above
the
reference
range
.
2
patients
received
antimycotic
treatment
:
one
patient
with
a
tormenting
dry
cough
subjectively
improved
under
Amphotericin
B
inhalation
;
one
patient
with
a
severe
exacerbation
due
to
T
.
inkin
was
treated
with
i
.
v
.
Amphotericin
B
,
oral
Voriconazole
and
Posaconazole
which
stabilized
the
clinical
condition
.
This
study
demonstrates
the
potential
association
of
Trichosporon
spp
.
with
severe
exacerbations
in
CF
patients
.
Diseases
Validation
Diseases presenting
"exhibited a stable clinical course determined by change in forced expiratory volume in one second"
symptom
allergic bronchopulmonary aspergillosis
You can validate or delete this automatically detected symptom
Validate the Symptom
Delete the Symptom