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[Analysis of clinical features and allergic status of asthmatic patients with positive serum mycosis-specific IgE].
[allergic bronchopulmonary aspergillosis]
To
improve
understanding
of
the
clinical
characteristics
and
diagnosis
of
allergic
bronchopulmonary
mycosis
(
ABPM
)
.
We
retrospectively
analyzed
the
clinical
data
,
including
clinical
symptoms
,
laboratory
tests
,
pulmonary
function
tests
and
chest
CT
imaging
of
95
asthmatic
patients
with
positive
serum
mycosis-
specific
IgE
from
January
2010
to
September
2012
in
Zhongshan
Hospital
Affiliated
to
Fudan
University
.
Of
the
95
patients
,
59
cases
met
the
diagnostic
criteria
of
ABPM
.
There
were
34
males
and
25
females
,
with
a
mean
age
of
(
53
±
4
)
years
and
a
duration
of
asthma
for
(
21
±
4
)
years
.
Thirty
-
six
cases
showed
mycosis
hypersensitivity
(
MH
)
.
There
were
10
males
and
26
females
,
with
a
mean
age
of
(
46
±
6
)
years
and
a
duration
of
asthma
for
(
16
±
5
)
years
.
Clinical
symptoms
such
as
wheeze
(
52
vs
21
,
χ
(
2
)
=
11
.
159
,
P
=
0
.
001
)
,
cough
(
54
vs
27
,
χ
(
2
)
=
4
.
859
,
P
=
0
.
030
)
and
expectoration
(
43
vs
9
,
χ
(
2
)
=
25
.
731
,
P
=
0
.
000
)
were
more
common
in
the
ABPM
group
compared
to
the
MH
group
.
In
the
ABPM
group
,
58
were
A
.
fumigatus-
specific
IgE
antibody
positive
,
34
Penicillium-
specific
IgE
antibody
positive
and
1
only
Penicillium-
specific
IgE
antibody
positive
.
W
hile
in
the
MH
group
,
15
were
A
.
fumigatus-
specific
IgE
antibody
positive
,
24
Penicillium-
specific
IgE
antibody
positive
and
17
only
Penicillium-
specific
IgE
antibody
positive
.
In
the
ABPM
group
,
the
percentage
of
positive
fumigatus-
specific
IgE
antibody
was
higher
(
58
vs
15
,
χ
(
2
)
=
24
.
500
,
P
=
0
.
000
)
,
while
the
percentages
of
dermatophagoides
pteronyssinus
(
21
vs
20
,
χ
(
2
)
=
3
.
632
,
P
=
0
.
045
)
and
Dermatophagoides
farinae
(
17
vs
21
,
χ
(
2
)
=
8
.
118
,
P
=
0
.
004
)
were
lower
.
Total
serum
IgE
[
(
4395
±
1437
)
IU
/
ml
vs
(
276
±
133
)
IU
/
ml
,
T
=
4
.
384
,
P
=
0
.
000
]
,
peripheral
eosinophil
percentage
[
(
12
.
56
±
1
.
20
)
%
vs
(
1
.
30
±
0
.
15
)
%
,
t
=
8
.
175
,
P
=
0
.
000
]
and
count
[
(
2
.
09
±
0
.
43
)
×
10
(
9
)
/
L
vs
(
0
.
19
±
0
.
04
)
×
10
(
9
)
/
L
,
t
=
7
.
032
,
P
=
0
.
000
]
were
higher
in
the
ABPM
group
as
compared
to
the
MH
group
.
FEV
1
%
slightly
declined
in
the
ABPM
group
[
(
70
.
2
±
2
.
3
)
%
vs
(
78
.
3
±
3
.
2
%
)
%
,
t
=
2
.
011
,
P
=
0
.
038
]
.
Forty
-
one
cases
(
69
.
50
%
)
had
central
bronchiectasis
and
18
(
30
.
50
%
)
had
mucus
plugs
in
the
ABPM
group
.
Chest
CT
scan
was
normal
in
the
MH
group
.
ABPM
is
common
in
asthmatic
patients
but
has
long
been
underestimated
and
misdiagnosed
.
Efforts
need
to
be
intensified
to
improve
the
awareness
among
clinicians
for
early
diagnosis
and
treatment
of
the
disease
.
Diseases
Validation
Diseases presenting
"total serum"
symptom
allergic bronchopulmonary aspergillosis
oral submucous fibrosis
waldenström macroglobulinemia
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