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Autonomic innervation of the intestine from a baby with megacystis microcolon intestinal hypoperistalsis syndrome: I. Immunohistochemical study.
[megacystis-microcolon-intestinal hypoperistalsis syndrome]
A
typical
case
of
megacystis
microcolon
intestinal
hypoperistalsis
syndrome
(
MMIHS
)
is
reported
.
The
patient
,
an
infant
girl
,
was
fed
only
by
total
intravenous
nutrition
and
is
now
3
years
old
.
The
distribution
of
several
gut
peptides
was
examined
in
the
resected
small
intestine
using
an
immunohistochemical
method
.
Vasoactive
intestinal
polypeptide
(
VIP
)
and
peptide
histidine
methionine
(
PHM
)
-
containing
nerve
fibers
were
decreased
;
however
,
substance
P-
and
leucine
enkephalin
(
Leu
-
ENK
)
-
containing
fibers
were
increased
.
The
imbalance
between
several
kinds
of
gut
peptides
might
be
one
the
causes
of
aperistalsis
in
MMIHS
.
This
is
the
first
report
about
the
gut
peptides
of
MMIHS
.
Diseases
Validation
Diseases presenting
"first report about the gut peptides"
symptom
megacystis-microcolon-intestinal hypoperistalsis syndrome
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