Prenatal diagnosis of megacystis-microcolon-intestinal hypoperistalsis syndrome in one fetus of a twin pregnancy.

[megacystis-microcolon-intestinal hypoperistalsis syndrome]

Megacystis-microcolon -intestinal hypoperistalsis syndrome (MMIHS ) is a rare genetic disorder that affects the muscle tone in the intestinal and urinary tract systems . Prenatal diagnosis is difficult because an identifiable genetic locus is absent and there are no specific ultrasound findings . We present an interesting case of this syndrome diagnosed prenatally in one fetus of a twin pregnancy . A 26 -year -old white woman gravida 4 , para 2103 , at 11 weeks ' gestation was diagnosed with a dichorionic diamniotic twin pregnancy . The patient 's history was significant for having a previous female infant diagnosed with MMIHS . During a follow-up ultrasound at 26 weeks , one of the twins had multiple anomalies including : a pelvic cystic structure with a keyhole appearance , enlarged stomach , dilated bowel , and prominent renal pelves . Prenatal diagnosis of MMIHS can be possible on ultrasound findings with a positive family history .