Antiphospholipid syndrome.

[malignant atrophic papulosis]

The antiphospholipid antibodies (aPL ), namely , the lupus anticoagulant and the anticardiolipin antibodies , are a family of autoantibodies directed predominantly against negatively charged phospholipids . Many studies have confirmed that patients with these antibodies are prone to repeated episodes of thrombosis , fetal losses , and thrombocytopenia . The association of aPL with these clinical events has been termed the antiphospholipid syndrome . Several skin lesions have been found in patients with this syndrome , including livedo reticularis , livedoid vasculitis , thrombophlebitis , cutaneous infarctions and gangrene of digits , ulcerations , lesions resembling vasculitis (nodules , macules ), cutaneous necrosis /infarctions , subungual splinter hemorrhages , and , less commonly , discoid lupus and Degos ' disease (malignant atrophic papulosis ). In this article , we review the main immunologic and clinical aspects of this syndrome with special emphasis on the dermatologic features .

Diseases
Validation

Diseases presenting "episodes of thrombosis" symptom

malignant atrophic papulosis

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