Malignant atrophic papulosis. A report of two cases with altered fibrinolysis and platelet function.

[malignant atrophic papulosis]

Malignant atrophic papulosis is a systemic vaso-occlusive disorder characterized by typical skin lesions . We report two new cases with impairment of blood fibrinolytic activity and alterations in platelet function . The first case showed an increase in plasminogen activator inhibitor-1 (PAI-1 ) activity , and the second case had a decrease in platelet aggregation induced by adenosine diphosphate and adrenaline but normal with collagen . The impairment of blood fibrinolytic activity and platelet aggregation may have pathogenic and therapeutic implications in malignant atrophic papulosis .