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[Malignant atrophic papulosis].
[malignant atrophic papulosis]
A
53
-
year
-old
woman
had
noticed
numerous
papules
on
her
trunk
and
proximal
parts
of
the
limbs
.
They
had
healed
with
a
central
scar
surrounded
by
a
reddish
wall
.
Four
months
later
she
had
to
undergo
laparotomy
for
ileus
,
resulting
from
a
perforation
in
the
region
of
the
middle
jejunum
:
it
was
excised
and
sutured
over
.
At
laparotomy
white
plaque-like
lesions
were
noted
on
the
serosa
of
both
small
and
large
intestine
.
Histological
examination
of
the
jejunal
exudate
and
of
a
skin
biopsy
both
demonstrated
malignant
atrophic
papulosis
(
Köhlmeier-
D
égos
'
disease
)
.
Treatment
with
ticlopidine
,
a
platelet
-aggregation
inhibitor
(
250
mg
twice
daily
)
,
was
initiated
and
she
has
now
been
free
of
extracutaneous
symptoms
for
6
years
.
Diseases
Validation
Diseases presenting
"central scar"
symptom
malignant atrophic papulosis
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