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[Malignant atrophic papulosis (Köhlmeier-Degos disease). Failure to respond to interferon alpha-2a, pentoxifylline and aspirin].
[malignant atrophic papulosis]
A
45
year
old
female
patient
presented
with
the
cutaneous
manifestations
of
malignant
atrophic
papulosis
(
Köhlmeier-
Degos
disease
)
for
two
years
.
The
typical
papules
with
central
porcelain-
white
atrophy
correspond
histologically
to
wedge-shaped
necrosis
of
the
connective
tissue
due
to
thrombotic
occlusion
of
small
vessels
in
the
corium
.
The
pathogenesis
of
malignant
atrophic
papulosis
and
effective
treatment
modalities
are
unknown
.
A
slow
virus
infection
has
been
suggested
by
some
authors
.
Therefore
,
we
attempted
an
immune
therapy
with
interferon
alpha-
2
a
over
a
period
of
11
months
,
but
failed
to
cause
a
significant
effect
on
the
appearance
and
progression
of
the
skin
lesions
.
Furthermore
,
we
could
not
confirm
the
effectiveness
of
a
recently
reported
treatment
modality
with
pentoxifylline
and
aspirin
administered
to
our
patient
over
a
period
of
5
months
.
