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Omalizumab, an anti-immunoglobulin E antibody: state of the art.
[allergic bronchopulmonary aspergillosis]
A
large
number
of
trials
show
that
the
anti-immunoglobulin
(
Ig
)
E
antibody
omalizumab
is
very
effective
in
patients
with
severe
allergic
asthma
.
This
is
acknowledged
in
consensus
documents
.
The
drug
also
has
a
good
safety
profile
and
a
pharmacoeconomic
advantage
due
to
a
reduction
in
the
number
of
hospitalizations
for
asthma
attacks
.
In
recent
years
,
some
studies
have
shown
that
omalizumab
is
effective
also
in
nonallergic
asthma
.
Effects
on
the
complex
signaling
mechanisms
leading
to
activation
of
effector
cells
and
to
mediator
release
may
account
for
this
outcome
.
Indeed
,
omalizumab
has
been
reported
to
be
effective
in
a
number
of
IgE-mediated
and
non-
IgE-mediated
disorders
.
Concerning
the
former
,
clinical
efficacy
has
been
observed
in
rhinitis
,
allergic
bronchopulmonary
aspergillosis
,
latex
allergy
,
atopic
dermatitis
,
allergic
urticaria
,
and
anaphylaxis
.
In
addition
,
omalizumab
has
been
demonstrated
to
be
able
to
prevent
systemic
reactions
to
allergen
immunotherapy
,
thus
enabling
completion
of
treatment
in
patients
who
otherwise
would
have
to
stop
it
.
Concerning
non-
IgE-mediated
disorders
,
omalizumab
has
been
reported
to
be
effective
in
nasal
polyposis
,
autoimmune
urticaria
,
chronic
idiopathic
urticaria
,
physical
urticaria
,
idiopathic
angioedema
,
and
mastocytosis
.
Current
indications
for
treatment
with
omalizumab
are
confined
to
severe
allergic
asthma
.
Consequently
,
any
other
prescription
can
only
be
off-label
.
However
,
it
is
reasonable
to
expect
that
the
use
of
omalizumab
will
be
approved
for
particularly
important
indications
,
such
as
anaphylaxis
,
in
the
near
future
.
Diseases
Validation
Diseases presenting
"to mediator release may account for this outcome"
symptom
allergic bronchopulmonary aspergillosis
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