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Role of inhaled amphotericin in allergic bronchopulmonary aspergillosis.
[allergic bronchopulmonary aspergillosis]
Allergic
bronchopulmonary
aspergillosis
(
ABPA
)
is
an
immunological
pulmonary
disorder
caused
by
immune
reactions
mounted
against
the
ubiquitous
fungus
Aspergillus
fumigatus
.
The
disease
clinically
manifests
with
poorly
controlled
asthma
,
hemoptysis
,
systemic
manifestations
like
fever
,
anorexia
and
weight
loss
,
fleeting
pulmonary
opacities
and
bronchiectasis
.
The
natural
course
of
the
disease
is
characterized
by
repeated
episodes
of
exacerbations
.
Almost
30
-
40
%
of
the
patients
require
prolonged
therapy
,
which
currently
consists
of
corticosteroids
and
anti-fungal
azoles
;
both
these
agents
have
significant
adverse
reactions
.
Amphotericin
B
administered
via
the
inhaled
route
can
achieve
a
high
concentration
in
the
small
airways
with
minimal
systemic
side-effects
.
Nebulized
amphotericin
B
has
been
used
in
the
management
of
invasive
pulmonary
aspergillosis
.
The
aim
of
this
review
is
to
study
the
utility
of
inhaled
amphotericin
in
ABPA
.
Diseases
Validation
Diseases presenting
"immune reactions mounted against the ubiquitous fungus aspergillus fumigatus"
symptom
allergic bronchopulmonary aspergillosis
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