Rare Diseases Symptoms Automatic Extraction
Home
A random Abstract
Our Project
Our Team
Sex-specific lung diseases: effect of oestrogen on cultured cells and in animal models.
[lymphangioleiomyomatosis]
Sex
prevalence
in
lung
disease
suggests
that
sex-
specific
hormones
may
contribute
to
the
pathogenesis
and
/
or
progression
of
at
least
some
lung
diseases
,
such
as
lung
adenocarcinoma
,
lymphangioleiomyomatosis
(
LAM
)
and
benign
metastasising
leiomyoma
(
BML
)
.
Oestrogen
is
an
important
hormone
in
normal
lung
development
and
in
the
pathogenesis
of
female
predominant
pulmonary
diseases
.
In
vivo
and
in
vitro
studies
have
facilitated
our
understanding
of
disease
pathogenesis
and
discovery
of
potential
therapeutic
targets
.
Oestrogen
promoted
disease
progression
in
cell
and
animal
models
of
lung
adenocarcinoma
,
LAM
and
BML
.
Specifically
,
oestrogen
enhanced
tumour
growth
and
metastasis
in
animal
models
of
these
diseases
.
Furthermore
,
17
β-estradiol
(
E
2
)
,
the
most
abundant
form
of
oestrogen
in
humans
,
increased
the
size
and
proliferation
of
cultured
cells
of
lung
adenocarcinoma
and
LAM
.
Coupled
with
the
known
mechanisms
of
oestrogen
metabolism
and
signalling
,
these
model
systems
may
provide
insights
into
the
diverse
effects
of
oestrogen
and
other
hormones
on
lung
diseases
.
Anti-oestrogen
treatments
that
target
key
events
of
oestrogen
synthesis
or
signalling
,
such
as
aromatase
activity
,
oestrogen
receptors
and
signalling
pathways
,
may
offer
additional
opportunities
for
clinical
trials
.
Diseases
Validation
Diseases presenting
"lung diseases"
symptom
allergic bronchopulmonary aspergillosis
lymphangioleiomyomatosis
You can validate or delete this automatically detected symptom
Validate the Symptom
Delete the Symptom