Rare Diseases Symptoms Automatic Extraction
Home
A random Abstract
Our Project
Our Team
Role of serum vascular endothelial growth factor D in discrimination of patients with polycystic lung diseases.
[lymphangioleiomyomatosis]
Polycystic
lung
diseases
(
PLDs
)
include
numerous
rare
diseases
including
lymphangioleiomyomatosis
(
LAM
)
,
pulmonary
Langerhans
cell
histiocytosis
(
PLCH
)
,
and
lymphocytic
interstitial
pneumonia
.
In
these
cases
,
diagnosis
is
based
on
a
histological
examination
of
open
lung
biopsy
samples
;
however
,
it
is
not
always
possible
to
perform
this
procedure
.
Serum
markers
characteristic
for
a
given
entity
are
still
being
sought
.
The
aim
of
the
study
was
to
determine
the
usefulness
of
assessing
serum
vascular
endothelial
growth
factor
D
(
VEGF‑D
)
concentration
in
the
differential
diagnosis
of
LAM
and
other
PLDs
(
OPLDs
)
.
Serum
VEGF‑D
levels
were
measured
by
an
enzyme‑linked
immunosorbent
assay
in
75
patients
with
PLDs
including
29
women
with
LAM
and
46
patients
with
OPLDs
(
28
women
and
18
men
)
.
Serum
VEGF‑D
levels
were
significantly
higher
in
patients
with
LAM
(
median
,
1557
pg
/
ml
;
interquartile
range
[
IQR
]
,
636
-
2593
pg
/
ml
)
than
in
all
patients
with
OPLDs
(
median
,
292
pg
/
ml
;
IQR
,
233
-
405
pg
/
ml
,
P
<
0
.
0001
)
or
than
in
women
with
OPLDs
(
median
,
344
pg
/
ml
;
IQR
,
243
-
452
pg
/
ml
,
P
<
0
.
0001
)
.
The
serum
VEGF‑D
level
exceeding
468
pg
/
ml
identified
LAM
patients
with
the
specificity
of
90
%
and
sensitivity
of
87
%
(
area
under
the
curve
of
0
.
908
;
95
%
confidence
interval
,
0
.
820
-
0
.
996
)
.
In
none
of
the
patients
with
OPLDs
serum
VEGF‑D
concentrations
exceeded
800
pg
/
ml
.
An
increased
serum
VEGF‑D
level
is
a
highly
specific
biomarker
useful
in
a
differential
diagnosis
of
LAM
and
OPLDs
.
Diseases
Validation
Diseases presenting
"lung diseases"
symptom
allergic bronchopulmonary aspergillosis
lymphangioleiomyomatosis
You can validate or delete this automatically detected symptom
Validate the Symptom
Delete the Symptom