A pilot study assessing the effect of bronchodilator on dynamic hyperinflation inÂ LAM.

[lymphangioleiomyomatosis]

Positive responses to bronchodilators (BDs ) on spirometry can be found in up to 30 % of patients with lymphangioleiomyomatosis (LAM ). However , no previous studies have investigated the impact of BDs on exercise outcomes , including dynamic hyperinflation (DH ).A randomised , double -blind , placebo-controlled , crossover trial was conducted on 38 patients with LAM , comparing inhaled placebo versus salbutamol . Pulmonary function tests and a cycle endurance test at 75 % of the maximal work capacity , with evaluation of DH by serial measurement of inspiratory capacity (IC ), which was the primary endpoint , were performed after each intervention .Although salbutamol produced a slight improvement in airway obstruction , compared with placebo , there was no significant variation in resting IC or air trapping . A total of 18 % of the patients met the criteria for a positive response to BD . During submaximal exercise , BD did not reduce DH or dyspnoea nor did it improve exercise tolerance in the entire population . In addition , BD produced only slight improvement in FEV 1 and air trapping in patients who had DH during incremental cardiopulmonary exercise testing , without the beneficial effects on exercise outcomes .Although salbutamol produced a slight improvement in airway obstruction , it did not lead to a reduction in DH or increase in exercise tolerance in patients with LAM .B razilian Registry of Clinical Trials (ReBEC ); www .ensaiosclinicos .gov .br ; registration number : RBR-49 sk 2 j .

Diseases
Validation

Diseases presenting "incremental cardiopulmonary exercise testing" symptom

lymphangioleiomyomatosis

You can validate or delete this automatically detected symptom