Role of nebulized amphotericin B in the management of allergic bronchopulmonary aspergillosis in cystic fibrosis: case report and review of literature.

[allergic bronchopulmonary aspergillosis]

Objectives : To review the data available in literature about nebulized amphotericin B (AMB ) in the treatment of allergic bronchopulmonary aspergillosis (ABPA ) in cystic fibrosis (CF ) and to report our experience in the use of this drug , with a particular therapeutic scheme . Case Report : We used nebulized liposomal amphotericin B (L-AMB ) in a patient affected by CF , complicated by ABPA . The previous combined treatment with oral steroids and azoles had no respiratory benefit and caused relevant side effects . Amphotericin B has always been well tolerated and permitted a slight steroid tapering . We also observed benefits in pulmonary function and laboratory tests . Conclusions : Few data are available in literature about the use of nebulized AMB in CF and there are no RCTs evaluating antifungals in CF -ABPA . In our opinion , the reported case suggests that nebulized L-AMB could represent a possible strategy in ABPA management in CF patients .

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allergic bronchopulmonary aspergillosis

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