Rare Diseases Symptoms Automatic Extraction
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A random Abstract
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Quality of life of ALS and LIS patients with and without invasive mechanical ventilation.
[locked-in syndrome]
There
are
very
few
studies
where
quality
of
life
(
QOL
)
is
assessed
in
patients
with
complete
physical
and
functional
disability
and
dependence
to
invasive
mechanical
ventilation
(
IV
)
.
We
compared
QOL
of
amyotrophic
lateral
sclerosis
(
ALS
)
and
locked-
in
-syndrome
(
LIS
)
patients
with
invasive
mechanical
ventilation
to
ALS
and
LIS
patients
without
mechanical
invasive
ventilation
.
Thirty
-
four
patients
,
27
with
ALS
and
seven
with
LIS
(
vascular
or
tumoral
aetiology
)
were
included
in
the
study
.
Twelve
had
invasive
ventilation
,
22
had
non-invasive
ventilation
,
and
in
the
non-invasive
ventilation
group
,
five
of
them
had
ventilation
via
mask
.
The
following
scales
were
used
for
patients
:
ALS
Functional
Rating
Scale
(
ALSFRS
)
,
McGILL
,
Short
-
Form
36
(
SF
36
)
,
Beck
Depression
Inventory-
II
,
the
Toronto
Alexithymia
Scale
and
the
anxiety
inventory
of
Spielberger
.
Mean
ALSFRS
scores
were
significantly
lower
in
the
invasive
ventilation
group
(
IV
)
than
in
the
non-invasive
ventilation
group
.
McGILL
and
SF
36
were
not
significantly
different
between
the
IV
group
and
the
non-invasive
ventilation
group
;
there
were
no
significant
differences
between
the
two
groups
for
others
scales
either
.
Comparison
between
IV
group
and
LIS
without
invasive
mechanical
ventilation
revealed
no
significant
difference
for
SF
36
and
McGILL
QOL
scores
.
QOL
was
not
significantly
different
between
the
IV
and
not
invasively
ventilated
patients
,
but
ALSFRS
was
significantly
lower
in
the
IV
group
,
and
comparison
of
QOL
scores
between
non-ventilated
LIS
patients
who
had
the
same
score
of
dependence
that
invasively
ventilated
patients
did
not
show
any
difference
.
Invasive
mechanical
ventilation
for
patients
who
accept
tracheotomy
allows
life
prolongation
and
their
QOL
is
not
affected
;
medical
teams
should
be
aware
of
that
.
Diseases
Validation
Diseases presenting
"depression"
symptom
22q11.2 deletion syndrome
achondroplasia
adrenal incidentaloma
adrenomyeloneuropathy
alexander disease
aromatase deficiency
cadasil
child syndrome
classical phenylketonuria
congenital adrenal hyperplasia
congenital toxoplasmosis
cushing syndrome
cutaneous mastocytosis
dracunculiasis
fabry disease
familial hypocalciuric hypercalcemia
gm1 gangliosidosis
hereditary cerebral hemorrhage with amyloidosis
krabbe disease
locked-in syndrome
malignant atrophic papulosis
oligodontia
oral submucous fibrosis
phenylketonuria
sneddon syndrome
triple a syndrome
trochlear dysplasia
von hippel-lindau disease
This symptom has already been validated