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Locked-in syndrome in three children with Guillain-Barré syndrome.
[locked-in syndrome]
Locked-
in
syndrome
is
a
rare
disorder
in
childhood
.
It
resembles
brain
death
,
but
patients
are
fully
conscious
,
and
incapable
of
communicating
because
of
the
complete
paralysis
of
voluntary
muscles
.
Although
it
can
be
caused
by
Guillain-
Barré
syndrome
,
it
is
rarely
reported
in
pediatrics
.
We
describe
three
pediatric
cases
of
locked-
in
syndrome
in
patients
with
Guillain-
Barré
syndrome
presenting
acute
tetraplegia
,
areflexia
,
cranial
nerve
involvement
,
and
albuminocytologic
dissociation
in
the
cerebrospinal
fluid
.
Electrophysiologic
studies
indicated
acute
motor
axonal
polyradiculoneuropathy
in
one
patient
,
and
acute
motor
sensory
axonal
polyradiculoneuropathy
in
the
other
two
.
Most
Guillain-
Barré
syndrome
patients
with
locked-
in
syndrome
demonstrate
nerve
inexcitability
in
neurophysiologic
studies
,
poor
clinical
outcomes
,
and
increased
risk
of
sequelae
.
Diseases
Validation
Diseases presenting
"acute tetraplegia"
symptom
locked-in syndrome
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