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A random Abstract
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What is the importance of classifying Aspergillus disease in cystic fibrosis patients?
[allergic bronchopulmonary aspergillosis]
Aspergillus
species
are
commonly
isolated
from
lower
respiratory
tract
samples
of
patients
with
cystic
fibrosis
(
CF
)
and
markers
of
immunological
sensation
to
Aspergillus
are
frequently
encountered
in
this
group
of
patients
;
however
,
the
contribution
of
Aspergillus
to
CF
lung
disease
outside
of
the
typical
complications
of
ABPA
and
aspergilloma
formation
remains
largely
unclear
.
Patients
with
CF
show
discretely
different
responses
to
Aspergillus
,
though
the
underlying
reasons
for
this
variation
are
unknown
.
Recent
work
has
begun
to
allow
us
to
categorize
patient
responses
to
Aspergillus
based
upon
molecular
markers
of
infection
and
immune
sensitization
.
Aspergillus
sensitization
and
/
or
airway
infection
is
associated
with
worse
FEV
1
,
in
CF
and
other
patients
(
asthma
,
chronic
obstructive
pulmonary
disease
,
bronchiectasis
)
.
Classification
of
different
clinical
phenotypes
of
Aspergillus
will
enable
future
studies
to
determine
the
natural
history
of
different
manifestations
of
Aspergillus
disease
and
evaluate
the
effects
of
intervention
with
antifungal
therapy
.
