Rare Diseases Symptoms Automatic Extraction
Home
A random Abstract
Our Project
Our Team
Catastrophic demyelinating encephalomyelitis after intrathecal and intravenous stem cell transplantation in a patient with multiple sclerosis.
[locked-in syndrome]
Stem
cell
transplantation
is
an
investigational
therapy
for
multiple
sclerosis
.
The
authors
describe
a
case
of
catastrophic
demyelinating
encephalomyelitis
following
stem
cell
transplantation
in
a
17
-
year
-old
girl
.
Nine
months
after
an
initial
diagnosis
of
multiple
sclerosis
,
she
underwent
stem
cell
transplantation
in
Costa
Rica
.
Subsequently
,
she
deteriorated
and
was
transported
back
to
the
United
States
with
headache
and
vomiting
progressing
to
quadriparesis
,
locked-
in
syndrome
,
and
superimposed
encephalopathy
.
Magnetic
resonance
imaging
and
brain
biopsy
were
consistent
with
fulminant
demyelinating
encephalomyelitis
with
enhancing
parenchyma
and
leptomeninges
.
Cerebrospinal
fluid
analysis
revealed
lymphocytic
pleocytosis
and
high
protein
.
The
protracted
illness
required
tracheostomy
and
gastrostomy
.
After
methyleprednisone
,
intravenous
immunoglobulin
,
and
cyclophosphamide
,
she
improved
during
2
.
5
months
to
an
ambulatory
,
functionally
independent
state
.
Subsequently
,
typical
less
severe
multiple
sclerosis
relapses
occurred
.
This
case
demonstrates
that
stem
cell
transplantation
may
provoke
life-threatening
encephalomyelitis
in
patients
with
multiple
sclerosis
.
This
highlights
the
need
to
restrict
transplantation
to
trials
with
appropriate
safety
controls
.
Diseases
Validation
Diseases presenting
"brain biopsy"
symptom
erdheim-chester disease
locked-in syndrome
severe combined immunodeficiency
sneddon syndrome
You can validate or delete this automatically detected symptom
Validate the Symptom
Delete the Symptom