Rare Diseases Symptoms Automatic Extraction
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Instrumental methods in the diagnostics of locked-in syndrome.
[locked-in syndrome]
The
locked-
in
syndrome
(
LiS
)
is
typically
characterized
by
a
paralysis
of
almost
all
body
muscles
combined
with
intact
cognitive
functions
.
In
practice
,
there
are
often
additional
brain
damages
besides
the
one
directly
causing
LiS
.
These
damages
can
lead
to
cognitive
impairment
,
which
substantially
complicates
the
diagnosis
of
LiS
.
At
the
level
of
behavior
,
therefore
,
the
disease
can
be
confused
with
akinetic
mutism
,
vegetative
state
(
syn
.
unresponsive
wakefulness
state
)
and
some
other
conditions
.
Using
instrumental
methods
in
addition
to
behavioral
diagnostics
helps
to
avoid
diagnostic
errors
and
to
improve
prognosis
of
rehabilitation
of
such
patients
.
These
methods
,
which
include
measurements
of
brain
electric
or
magnetic
fields
,
electrical
potential
of
muscles
,
blood
flow
and
oxygen
consumption
in
the
brain
,
are
reviewed
in
this
paper
.