Rare Diseases Symptoms Automatic Extraction
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Fragmentation of slow wave sleep after onset of complete locked-in state.
[locked-in syndrome]
Locked-
in
syndrome
(
LIS
)
as
a
result
of
brainstem
lesions
or
progressive
neurodegenerative
disorders
,
such
as
amyotrophic
lateral
sclerosis
(
ALS
)
,
is
a
severe
medical
condition
in
which
a
person
is
fully
conscious
but
unable
to
move
or
talk
.
LIS
can
transition
into
complete
locked-
in
syndrome
(
CLIS
)
in
which
residual
abilities
to
communicate
through
muscle
twitches
are
entirely
lost
.
It
is
unknown
how
CLIS
affects
circadian
rhythm
and
sleep
/
wake
patterns
.
Here
we
report
a
39
-
year
-old
ALS
patient
who
transitioned
from
LIS
to
CLIS
while
brain
activity
was
continuously
recorded
using
electrocorticography
(
ECoG
)
over
one
month
.
While
we
found
no
circadian
rhythm
in
heart
rate
and
body
temperature
,
transition
into
CLIS
was
associated
with
increased
fragmentation
of
slow
wave
sleep
(
SWS
)
across
the
day
.
Total
time
in
SWS
did
not
change
.
SWS
fragmentation
might
reflect
progressive
circadian
system
impairment
and
should
be
considered
as
a
factor
further
limiting
communication
capabilities
in
these
patients
.