Lipoblast: morphologic features and diagnostic value.

[liposarcoma]

Lipoblasts are conceptually a precursor or immature form of adipocytes and histologically defined as lipid-containing , monoï¼ or multivacuolated cells possessing hyperchromatic , indented or often scalloped nuclei . They are essentially identified in neoplastic conditions and assumed to recapitulate , to some extent , the differentiation process of normal fat (adipogenesis ) like their potential normal counterpart , preadipocyte or preadipose cell . Traditionally , great emphasis has been placed on the identification of lipoblasts in diagnostic pathology , particularly of liposarcoma . However , it is not always an easy task for pathologists because of a variety of histological mimics such as Lochkern cells , brown fat cells and pseudolipoblasts . Currently , lipoblasts are not a prerequisite for the diagnosis of liposarcoma partly because of some benign tumors harboring lipoblasts or lipoblast-like cells such as spindle cell /pleomorphic lipoma and chondroid lipoma , although their presence is still crucial for proper diagnosis . This review summarizes the clinicopathologic features of lipoblasts , their histological mimics and representative benign tumors carrying lipoblasts to facilitate routine pathology practice and to avoid erroneous diagnosis of liposarcoma .

Diseases
Validation

Diseases presenting "often scalloped nuclei" symptom

liposarcoma

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