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Dendritic fibromyxolipoma: a variant of spindle cell lipoma with extensive myxoid change, with cytogenetic evidence.
[liposarcoma]
Dendritic
fibromyxolipoma
(
DFML
)
,
a
rare
,
recently
described
distinct
benign
soft
tissue
tumor
,
has
many
clinicopathological
features
reminiscent
of
spindle
cell
lipoma
and
solitary
fibrous
tumor
with
myxoid
change
.
It
is
distinguished
histologically
from
both
entities
by
the
presence
of
spindle
and
stellate
cells
with
dendritic
cytoplasmic
prolongations
,
prominent
myxoid
stroma
with
abundant
keloidal
collagen
and
occasional
small
plexiform
vascular
proliferation
.
We
describe
a
case
of
histologically
confirmed
DFML
of
the
left
shoulder
in
a
67
-
year
-old
male
,
in
which
subsequent
cytogenetic
analysis
revealed
deletion
involving
13
q
14
.
3
region
in
all
the
tumor
cells
,
typically
detected
in
spindle
cell
lipoma
.
In
the
presence
of
many
clinicopathological
similarities
between
DFML
and
spindle
cell
lipoma
including
chromosomal
abnormalities
,
we
postulate
that
DFML
is
merely
a
rare
variant
of
spindle
cell
lipoma
with
extensive
myxoid
degeneration
,
and
may
not
be
considered
as
a
separate
entity
.
The
possible
differential
diagnosis
and
their
distinguishing
features
are
briefly
discussed
.