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Cell senescence in myxoid/round cell liposarcoma.
[liposarcoma]
Myxoid
/
round
cell
liposarcoma
(
MLS
/
RCLS
)
is
the
second
most
common
liposarcoma
type
and
characterized
by
the
fusion
oncogenes
FUS
-
DDIT
3
or
EWSR
1
-
DDIT
3
.
Previous
analysis
of
cell
cycle
regulatory
proteins
revealed
a
prominent
expression
of
G
1
-
cyclins
,
cyclin
dependent
kinases
,
and
their
inhibitors
but
very
few
cells
progressing
through
the
G
1
/
S
boundary
.
Here
,
we
extend
the
investigation
to
proteins
involved
in
cell
senescence
in
an
immunohistochemistry
based
study
of
17
MLS
/
RCLS
cases
.
Large
subpopulations
of
tumor
cells
expressed
the
RBL
2
pocket
protein
and
senescence
associated
heterochromatin
1
γ
and
IL
8
receptor
β
.
We
conclude
that
MLS
/
RCLS
tissues
contain
major
populations
of
senescent
tumor
cells
and
this
may
explain
the
slow
growth
rate
of
this
tumor
type
.
Diseases
Validation
Diseases presenting
"tumor cells"
symptom
alpha-thalassemia
carcinoma of the gallbladder
cholangiocarcinoma
cushing syndrome
dedifferentiated liposarcoma
dentin dysplasia
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
hodgkin lymphoma, classical
junctional epidermolysis bullosa
kindler syndrome
liposarcoma
lymphangioleiomyomatosis
pleomorphic liposarcoma
primary effusion lymphoma
severe combined immunodeficiency
triple a syndrome
von hippel-lindau disease
waldenström macroglobulinemia
well-differentiated liposarcoma
werner syndrome
wiskott-aldrich syndrome
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