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Cell senescence in myxoid/round cell liposarcoma.
[liposarcoma]
Myxoid
/
round
cell
liposarcoma
(
MLS
/
RCLS
)
is
the
second
most
common
liposarcoma
type
and
characterized
by
the
fusion
oncogenes
FUS
-
DDIT
3
or
EWSR
1
-
DDIT
3
.
Previous
analysis
of
cell
cycle
regulatory
proteins
revealed
a
prominent
expression
of
G
1
-
cyclins
,
cyclin
dependent
kinases
,
and
their
inhibitors
but
very
few
cells
progressing
through
the
G
1
/
S
boundary
.
Here
,
we
extend
the
investigation
to
proteins
involved
in
cell
senescence
in
an
immunohistochemistry
based
study
of
17
MLS
/
RCLS
cases
.
Large
subpopulations
of
tumor
cells
expressed
the
RBL
2
pocket
protein
and
senescence
associated
heterochromatin
1
γ
and
IL
8
receptor
β
.
We
conclude
that
MLS
/
RCLS
tissues
contain
major
populations
of
senescent
tumor
cells
and
this
may
explain
the
slow
growth
rate
of
this
tumor
type
.
Diseases
Validation
Diseases presenting
"common liposarcoma type"
symptom
liposarcoma
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