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Malignant mesenchymoma with widespread metastasis including bone marrow involvement in a dog.
[liposarcoma]
A
male
castrated
Golden
Retriever
was
presented
for
evaluation
of
a
large
mass
over
the
left
shoulder
extending
to
the
lower
part
of
the
neck
that
had
been
present
for
an
extended
period
of
time
,
but
had
a
recent
history
of
rapid
growth
.
Previous
aspirates
of
the
mass
were
consistent
with
a
lipoma
.
The
mass
was
surgically
excised
and
was
diagnosed
as
an
extraskeletal
osteosarcoma
based
on
histopathology
.
After
surgery
,
the
dog
was
initiated
on
a
chemotherapy
protocol
with
carboplatin
and
metronomic
cyclophosphamide
.
He
became
neutropenic
,
anemic
,
and
thrombocytopenic
14
days
after
the
carboplatin
treatment
was
administered
.
The
neutropenia
resolved
,
but
the
anemia
and
thrombocytopenia
progressed
.
A
bone
marrow
aspirate
revealed
erythroid
hypoplasia
,
myeloid
hyperplasia
with
a
predominance
of
early
precursors
,
and
a
subset
of
cells
that
made
up
20
%
of
the
total
population
that
were
reported
as
bizarre
and
unclassifiable
.
These
cells
were
discrete
in
nature
and
were
thought
to
be
hematopoietic
in
origin
.
The
dog
was
euthanized
due
to
deterioration
of
the
clinical
condition
.
On
postmortem
examination
,
widespread
metastasis
involving
the
lungs
,
liver
,
kidney
,
heart
,
and
bone
marrow
was
found
.
Histopathology
of
the
tumor
lesions
determined
2
distinct
malignant
populations
of
liposarcoma
and
osteosarcoma
,
consistent
with
malignant
mesenchymoma
.
However
,
the
possibility
of
2
separate
neoplastic
processes
can
not
be
definitively
excluded
.
This
is
the
first
report
of
bone
marrow
metastasis
of
a
malignant
mesenchymoma
in
a
dog
.
Diseases
Validation
Diseases presenting
"first report"
symptom
achondroplasia
alexander disease
aniridia
cadasil
canavan disease
child syndrome
cohen syndrome
congenital toxoplasmosis
cowden syndrome
cushing syndrome
cutaneous mastocytosis
cystinuria
dedifferentiated liposarcoma
dentinogenesis imperfecta
dracunculiasis
dystrophic epidermolysis bullosa
epidermolysis bullosa simplex
erdheim-chester disease
esophageal squamous cell carcinoma
fabry disease
familial mediterranean fever
focal myositis
harlequin ichthyosis
hirschsprung disease
hodgkin lymphoma, classical
holt-oram syndrome
homocystinuria without methylmalonic aciduria
inclusion body myositis
junctional epidermolysis bullosa
kabuki syndrome
kindler syndrome
krabbe disease
lamellar ichthyosis
liposarcoma
lymphangioleiomyomatosis
monosomy 21
neonatal adrenoleukodystrophy
neuralgic amyotrophy
oculocutaneous albinism
oligodontia
omenn syndrome
pendred syndrome
pleomorphic liposarcoma
primary hyperoxaluria type 1
pyomyositis
pyruvate dehydrogenase deficiency
scrub typhus
severe combined immunodeficiency
sneddon syndrome
triple a syndrome
typhoid
waldenström macroglobulinemia
werner syndrome
wiskott-aldrich syndrome
x-linked adrenoleukodystrophy
zellweger syndrome
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