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Malignant mesenchymoma with widespread metastasis including bone marrow involvement in a dog.
[liposarcoma]
A
male
castrated
Golden
Retriever
was
presented
for
evaluation
of
a
large
mass
over
the
left
shoulder
extending
to
the
lower
part
of
the
neck
that
had
been
present
for
an
extended
period
of
time
,
but
had
a
recent
history
of
rapid
growth
.
Previous
aspirates
of
the
mass
were
consistent
with
a
lipoma
.
The
mass
was
surgically
excised
and
was
diagnosed
as
an
extraskeletal
osteosarcoma
based
on
histopathology
.
After
surgery
,
the
dog
was
initiated
on
a
chemotherapy
protocol
with
carboplatin
and
metronomic
cyclophosphamide
.
He
became
neutropenic
,
anemic
,
and
thrombocytopenic
14
Â
days
after
the
carboplatin
treatment
was
administered
.
The
neutropenia
resolved
,
but
the
anemia
and
thrombocytopenia
progressed
.
A
bone
marrow
aspirate
revealed
erythroid
hypoplasia
,
myeloid
hyperplasia
with
a
predominance
of
early
precursors
,
and
a
subset
of
cells
that
made
up
20
%
of
the
total
population
that
were
reported
as
bizarre
and
unclassifiable
.
These
cells
were
discrete
in
nature
and
were
thought
to
be
hematopoietic
in
origin
.
The
dog
was
euthanized
due
to
deterioration
of
the
clinical
condition
.
On
postmortem
examination
,
widespread
metastasis
involving
the
lungs
,
liver
,
kidney
,
heart
,
and
bone
marrow
was
found
.
Histopathology
of
the
tumor
lesions
determined
2
distinct
malignant
populations
of
liposarcoma
and
osteosarcoma
,
consistent
with
malignant
mesenchymoma
.
However
,
the
possibility
of
2
separate
neoplastic
processes
can
not
be
definitively
excluded
.
This
is
the
first
report
of
bone
marrow
metastasis
of
a
malignant
mesenchymoma
in
a
dog
.
Diseases
Validation
Diseases presenting
"tumor lesions"
symptom
liposarcoma
thoracic outlet syndrome
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