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A questionnaire-based study on the role of environmental factors in allergic bronchopulmonary aspergillosis.
[allergic bronchopulmonary aspergillosis]
Allergic
bronchopulmonary
aspergillosis
(
ABPA
)
is
an
immunological
disorder
caused
by
hypersensitivity
against
Aspergillus
fumigatus
.
The
pathogenesis
of
ABPA
remains
unknown
.
Few
studies
have
investigated
the
role
of
environmental
factors
in
pathogenesis
of
ABPA
.
Herein
,
we
investigate
the
role
of
environmental
factors
in
ABPA
.
In
this
prospective
case-control
study
,
consecutive
patients
with
asthma
(
Aspergillus
sensitized
and
unsensitized
)
and
ABPA
were
investigated
using
a
standardized
questionnaire
to
enquire
into
their
demographic
characteristics
,
clinical
details
,
exposure
to
organic
matter
and
living
conditions
(
home
environment
,
presence
of
moisture
in
the
walls
,
and
others
)
.
Asthma
severity
and
control
was
assessed
using
the
2002
The
Global
Initiative
for
Asthma
(
GINA
)
recommendations
and
asthma
control
test
,
respectively
.
During
the
study
period
,
202
subjects
of
asthma
(
103
and
99
Aspergillus
unsensitized
and
sensitized
asthma
,
respectively
)
and
101
ABPA
with
a
mean
(
SD
)
age
of
35
.
3
(
14
.
7
)
years
were
included
.
The
baseline
characteristics
were
similar
in
the
two
groups
except
for
a
higher
prevalence
of
severe
persistent
asthma
in
the
ABPA
group
(
79
%
vs
.
44
%
,
P
=
0
.
0001
)
.
No
significant
differences
in
environmental
factors
were
noted
in
the
ABPA
population
compared
to
asthmatic
patients
except
for
a
higher
rural
residence
in
ABPA
(
47
%
vs
.
66
%
,
P
=
0
.
007
)
.
The
study
found
no
significant
environmental
differences
in
ABPA
compared
to
asthmatic
patients
.
It
is
likely
that
environmental
factors
are
not
the
primary
pathogenetic
factors
in
causation
of
ABPA
.
Diseases
Validation
Diseases presenting
"respectively"
symptom
adrenal incidentaloma
allergic bronchopulmonary aspergillosis
alpha-thalassemia
benign recurrent intrahepatic cholestasis
carcinoma of the gallbladder
congenital adrenal hyperplasia
congenital diaphragmatic hernia
congenital toxoplasmosis
cushing syndrome
cystinuria
dedifferentiated liposarcoma
dentin dysplasia
dentinogenesis imperfecta
epidermolysis bullosa simplex
esophageal squamous cell carcinoma
familial hypocalciuric hypercalcemia
harlequin ichthyosis
hereditary cerebral hemorrhage with amyloidosis
hirschsprung disease
hodgkin lymphoma, classical
holt-oram syndrome
kallmann syndrome
lamellar ichthyosis
liposarcoma
neonatal adrenoleukodystrophy
neuralgic amyotrophy
oculocutaneous albinism
oligodontia
oral submucous fibrosis
pendred syndrome
pleomorphic liposarcoma
primary effusion lymphoma
proteus syndrome
pyruvate dehydrogenase deficiency
scrub typhus
triple a syndrome
von hippel-lindau disease
well-differentiated liposarcoma
wolf-hirschhorn syndrome
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