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Ultrasound-guided fine-needle aspiration of a posterior neck dedifferentiated liposarcoma with MDM2 fluorescence in situ hybridization performed on a Pap-stained smear.
[liposarcoma]
Head
and
neck
liposarcomas
,
while
rare
,
tend
to
be
subcutaneous
and
well-differentiated
.
Dedifferentiated
liposarcomas
of
the
head
and
neck
are
exceedingly
rare
in
the
literature
.
We
present
a
case
of
a
dedifferentiated
liposarcoma
arising
in
the
soft
tissue
of
the
posterior
neck
of
an
86
-
year
-old
man
and
diagnosed
by
fine-needle
aspiration
.
Aspirate
smears
showed
a
dual
population
of
atypical
lipomatous
and
spindled
cells
.
MDM
2
(
murine
double
minute
2
)
amplification
was
demonstrated
on
a
Pap-stained
smear
using
fluorescence
in
situ
hybridization
(
FISH
)
.
To
the
best
of
our
knowledge
,
this
is
the
first
report
of
MDM
2
FISH
amplification
in
a
liposarcoma
performed
on
an
aspirate
smear
.
Diagn
.
Cytopathol
.
2014
.
©
2014
Wiley
Periodicals
,
Inc
.