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Relationship of angiogenic and apoptotic activities in soft-tissue sarcoma.
[liposarcoma]
Angiogenesis
and
apoptosis
play
an
essential
role
in
tumor
development
and
progression
.
Previous
studies
on
apoptosis
and
angiogenesis
of
soft
-tissue
sarcoma
(
STS
)
were
done
separately
.
This
is
the
first
study
of
the
relationship
between
apoptotic
and
angiogenic
activity
.
Correlation
of
expression
of
anti-apoptotic
protein
(
Bcl-
2
)
and
pro-apoptotic
protein
(
Bax
)
in
the
tumor
cells
(
TCs
)
with
their
expression
in
endothelial
cell
(
EC
)
of
the
tumor
blood
vessels
in
STS
were
also
carried
out
.
101
cases
of
STS
;
consisting
liposarcoma
,
malignant
fibrous
histiocytoma
,
synovial
sarcoma
,
fibrosarcoma
,
leiomyosarcoma
,
rhabdomyosarcoma
and
malignant
peripheral
nerve
sheath
tumor
;
were
collected
and
immunohistochemical
reaction
of
vascular
endothelial
growth
factor
(
VEGF
)
,
Bcl-
2
and
Bax
were
examined
.
Higher
Bax
expression
in
TCs
(
54
.
5
%
)
was
seen
compared
to
Bcl-
2
expression
(
44
.
6
%
)
.
There
was
a
significant
association
between
Bcl-
2
and
Bax
in
TCs
with
ECs
.
Significant
association
was
also
seen
between
histological
types
of
STS
with
Bcl-
2
expression
;
however
not
with
Bax
expression
.
There
was
an
association
between
VEGF
and
Bax
with
high
VEGF
expression
and
weak
Bax
expression
.
However
,
VEGF
expression
was
not
associated
with
Bcl-
2
expression
and
histological
types
.
This
study
supports
the
role
of
ECs
of
tumor
blood
vessels
and
apoptosis
of
TCs
in
tumor
management
.
Increased
angiogenesis
may
inhibit
apoptosis
of
TCs
and
lead
to
tumor
growth
.
Therefore
,
inhibition
of
ECs
survival
or
activation
of
ECs
death
is
promising
prospect
for
tumor
therapy
.
Immunohistochemical
antibodies
in
this
study
might
be
potential
useful
marker
for
the
prognosis
of
STS
.
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symptom
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