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Potassium channel ether à go-go1 is aberrantly expressed in human liposarcoma and promotes tumorigenesis.
[liposarcoma]
The
ether
Ã
go-go
1
(
Eag
1
)
channel
is
overexpressed
in
a
variety
of
cancers
.
However
,
the
expression
and
function
of
Eag
1
in
liposarcoma
are
poorly
understood
.
In
the
present
study
,
the
mRNA
expression
of
Eag
1
in
different
adipose
tissue
samples
was
examined
by
real-time
PCR
.
Then
,
the
protein
expression
of
Eag
1
in
131
different
adipose
tissues
from
109
patients
was
detected
by
immunohistochemistry
.
Next
,
the
associations
between
Eag
1
expression
and
clinicopathological
features
of
liposarcoma
were
analyzed
.
In
addition
,
the
effects
of
Eag
1
on
liposarcoma
cell
proliferation
and
cycle
were
evaluated
by
CCK
-
8
,
colony
formation
,
xenograft
mouse
model
,
and
flow
cytometry
,
respectively
.
Finally
,
the
activation
of
p
38
mitogen-activated
protein
kinase
(
MAPK
)
was
detected
by
Western
blot
analysis
to
explain
the
detailed
mechanisms
of
oncogenic
potential
of
Eag
1
in
liposarcoma
.
It
was
found
that
Eag
1
was
aberrantly
expressed
in
over
67
%
liposarcomas
,
with
a
higher
frequency
than
in
lipoma
,
hyperplasia
,
inflammation
,
and
normal
adipose
tissues
.
However
,
Eag
1
expression
was
not
correlated
with
clinicopathological
features
of
liposarcoma
.
Eag
1
inhibitor
imipramine
or
Eag
1
-
shRNA
significantly
suppressed
the
proliferation
of
liposarcoma
cells
in
vitro
and
in
vivo
,
accompanying
with
accumulation
of
cells
in
the
G
1
phase
.
These
results
suggest
that
Eag
1
plays
an
important
role
in
regulating
the
proliferation
and
cell
cycle
of
liposarcoma
cells
and
might
be
a
potential
therapeutic
target
for
liposarcoma
.
Diseases
Validation
Diseases presenting
"potential therapeutic target"
symptom
alexander disease
canavan disease
dedifferentiated liposarcoma
esophageal squamous cell carcinoma
familial hypocalciuric hypercalcemia
familial mediterranean fever
heparin-induced thrombocytopenia
krabbe disease
liposarcoma
lymphangioleiomyomatosis
primary effusion lymphoma
well-differentiated liposarcoma
werner syndrome
wiskott-aldrich syndrome
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