Diffuse Reactive Angioendotheliomatosis Secondary to the Administration of Trabectedin and Pegfilgrastim.

[liposarcoma]

: Diffuse dermal angiomatosis is a rare benign condition considered a variant of reactive angioendotheliomatosis , usually related to vascular disease such as arteriovenous fistula or severe peripheral vascular disease . The most frequent clinical manifestations range from a solitary erythematous patch to an indurated plaque that may ulcerate . A clinical case of a 60 -year -old woman who developed generalized livedoid lesions 2 days after the administration of intravenous trabectedin and subcutaneous pegfilgrastim for a recidivant myxoid liposarcoma has been reported . A biopsy of the skin lesions showed a pronounced proliferation of vessels in the upper dermis that was diagnosed as diffuse dermal angiomatosis .