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Bone and Soft Tissue Pathology: SC02-3 ANGIOFIBROMA OF SOFT TISSUE.
[liposarcoma]
Angiofibroma
of
soft
tissue
arising
in
the
thigh
of
a
54
-
year
-old
female
will
be
demonstrated
.
Grossly
,
well
circumscribed
tumor
showed
grayish
white
color
with
focal
gelatinous
appearance
on
its
cut
surface
.
Histologically
,
the
tumor
is
composed
of
oval
to
short
spindle-shaped
cells
arranged
in
patternless
pattern
,
accompanied
by
slit-like
or
hemangiopericytomatous
vessels
,
fibro-collagenous
or
myxoid
stroma
.
Immunohistochemically
,
tumor
cells
are
negative
for
CD
34
,
myogenic
,
myoepithelial
or
epithelial
markers
.
INI
1
expression
is
preserved
.
Characteristic
AHRR
-
NCOA
2
fusion
transcript
was
detected
by
RT-PCR
.
This
tumor
is
characterized
by
two
components
:
uniformly
proliferating
bland
spindle
shaped
cells
in
fibro-collagenous
or
myxoid
stroma
,
and
prominent
vascular
network
composed
of
small
,
branching
hemangiopericytomatous
,
and
thin
walled
blood
vessels
.
In
this
slide
seminar
detailed
clinicopathological
features
of
angiofibroma
of
soft
tissue
will
be
demonstrated
.
Moreover
,
the
differential
diagnosis
of
this
peculiar
tumor
including
cellular
angiofibroma
,
solitary
fibrous
tumor
,
low
-grade
fibromyxoid
sarcoma
and
low
-grade
myxofibrosarcoma
or
myxoid
/
round
cell
liposarcoma
will
be
explained
.
Diseases
Validation
Diseases presenting
"low-grade fibromyxoid sarcoma and low-grade myxofibrosarcoma or myxoid"
symptom
liposarcoma
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