Rare Diseases Symptoms Automatic Extraction

Omalizumab: a new treatment option for allergic bronchopulmonary aspergillosis in patients with cystic fibrosis.

[allergic bronchopulmonary aspergillosis]

Allergic bronchopulmonary aspergillosis (ABPA) is a severe complication in patients with cystic fibrosis (CF), resulting in deterioration of lung function and impairment of overall prognosis. Standard therapy consists of high dosage, long-term corticosteroid treatment. This carries the risk of serious side effects such as immune suppression, diabetes and osteoporosis. Antifungal drugs such as itraconazole may cause interactions with other drugs and drug levels need to be monitored. Omalizumab treatment has been tried in several case studies.This was a retrospective study of six patients (four female, two male, age 4-33 years old) with CF and ABPA treated with omalizumab within an observation period of 7.5 years.All patients showed clinical and laboratory stability or even an improvement within the treatment and post-treatment observation period, although omalizumab therapy was less effective in patients with progressed lung disease and long-term ABPA. Side effects of systemic steroids were reduced.Omalizumab has the potential to be an additional and solitary treatment option in patients with CF and ABPA. Early onset treatment may be beneficial and patients with early stage of lung disease seem to benefit more.

Diseases presenting "early stage" symptom

  • adrenomyeloneuropathy
  • allergic bronchopulmonary aspergillosis
  • aromatase deficiency
  • cadasil
  • carcinoma of the gallbladder
  • child syndrome
  • cholangiocarcinoma
  • congenital adrenal hyperplasia
  • esophageal adenocarcinoma
  • esophageal carcinoma
  • esophageal squamous cell carcinoma
  • familial hypocalciuric hypercalcemia
  • familial mediterranean fever
  • gm1 gangliosidosis
  • harlequin ichthyosis
  • hereditary cerebral hemorrhage with amyloidosis
  • hodgkin lymphoma, classical
  • kindler syndrome
  • lymphangioleiomyomatosis
  • neonatal adrenoleukodystrophy
  • pyomyositis
  • scrub typhus
  • sneddon syndrome
  • typhoid
  • von hippel-lindau disease
  • zellweger syndrome

You can validate or delete this automatically detected symptom