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The Caenorhabditis elegans model of Legionella infection.
[legionellosis]
Caenorhabditis
elegans
can
serve
as
a
simple
genetic
host
to
study
interactions
between
Legionellaceae
and
their
hosts
,
and
to
examine
the
contribution
of
specific
gene
products
to
virulence
and
immunity
.
C
.
elegans
nematodes
have
several
appealing
attributes
as
a
host
organism
;
they
are
inexpensive
,
have
robust
genetic
analysis
tools
,
have
a
simple
anatomy
yet
display
a
wide
range
of
complex
behaviors
,
and
,
as
invertebrates
,
do
not
require
animal
ethics
protocols
.
Use
of
C
.
elegans
as
a
host
model
complements
cell-based
models
,
providing
additional
support
and
consistency
of
the
experimental
data
obtained
from
multiple
models
.
The
C
.
elegans
innate
immune
system
functions
similarly
to
that
of
the
alveolar
macrophage
including
the
apoptosis
[
e
.
g
.
programmed
cell
death
(
PCD
)
]
pathway
located
within
the
germline
.
The
digestive
tract
of
C
.
elegans
is
a
primary
interface
between
the
innate
immune
system
and
bacterial
pathogens
.
Thus
,
the
C
.
elegans
host
model
provides
an
alternative
approach
to
investigate
Legionella
pneumophila
immunopathogenesis
.
