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Intra-amoeba multiplication induces chemotaxis and biofilm colonization and formation for Legionella.
[legionellosis]
Legionella
pneumophila
,
a
facultative
intracellular
bacterium
,
is
the
causative
agent
of
legionellosis
.
In
the
environment
this
pathogenic
bacterium
colonizes
the
biofilms
as
well
as
amoebae
,
which
provide
a
rich
environment
for
the
replication
of
Legionella
.
When
seeded
on
pre-formed
biofilms
,
L
.
pneumophila
was
able
to
establish
and
survive
and
was
only
found
at
the
surface
of
the
biofilms
.
Different
phenotypes
were
observed
when
the
L
.
pneumophila
,
used
to
implement
pre-formed
biofilms
or
to
form
mono-species
biofilms
,
were
cultivated
in
a
laboratory
culture
broth
or
had
grown
intracellulary
within
the
amoeba
.
Indeed
,
the
bacteria
,
which
developed
within
the
amoeba
,
formed
clusters
when
deposited
on
a
solid
surface
.
Moreover
,
our
results
demonstrate
that
multiplication
inside
the
amoeba
increased
the
capacity
of
L
.
pneumophila
to
produce
polysaccharides
and
therefore
enhanced
its
capacity
to
establish
biofilms
.
Finally
,
it
was
shown
that
the
clusters
formed
by
L
.
pneumophila
were
probably
related
to
the
secretion
of
a
chemotaxis
molecular
agent
.
Diseases
Validation
Diseases presenting
"pneumophila was able to establish and survive and"
symptom
legionellosis
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