Role of C-reactive protein as a biomarker for prediction of the severity of pulmonary exacerbations in patients with cystic fibrosis.

[allergic bronchopulmonary aspergillosis]

Pulmonary exacerbation is one of the main risk factors for death in patients with cystic fibrosis . Several biomarkers have proven useful in the diagnosis and treatment of pulmonary exacerbations , although none has been associated with severity . The objective of the present study was to investigate whether C-reactive protein (CRP ) level was associated with the severity of pulmonary exacerbation requiring admission to hospital in patients with cystic fibrosis .We designed a severity index for exacerbations based on 4 clinical parameters and determined whether there was an association between CRP levels and severity of the exacerbation . We also investigated the association between CRP and baseline functional and clinical variables .Twenty -seven patients with cystic fibrosis required 62 admissions to hospital . CRP levels were not significantly associated with the severity index , although they were associated with specific patient characteristics : colonization by Pseudomonas aeruginosa , allergic bronchopulmonary aspergillosis , treatment with oral corticosteroids , and number of severe exacerbations treated with intravenous antibiotics during the previous year .CRP level is not associated with the severity of pulmonary exacerbations , but it is associated with specific clinical characteristics . This simple scoring system (severity index ) could prove very useful for evaluating the severity of exacerbations .

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Diseases presenting "treatment with oral corticosteroids" symptom

allergic bronchopulmonary aspergillosis

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