Rare Diseases Symptoms Automatic Extraction
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Opportunistic infections in patients with pemphigus.
[legionellosis]
Opportunistic
infections
(
OIs
)
can
be
defined
as
infections
in
immunosuppressed
patients
that
are
more
frequent
or
severe
because
of
immunosuppression
.
The
literature
on
OIs
in
pemphigus
is
sparse
.
We
assessed
the
incidence
,
risk
factors
,
and
characteristics
of
OIs
in
patients
with
pemphigus
.
This
was
a
historical
prospective
study
following
a
cohort
of
172
patients
with
newly
diagnosed
pemphigus
for
the
development
of
OIs
.
Fourteen
patients
developed
OIs
at
a
mean
of
4
months
from
the
time
of
diagnosis
while
taking
a
mean
dose
of
0
.
8
mg
/
kg
/
day
of
prednisone
,
5
in
conjunction
with
azathioprine
.
The
risk
of
developing
an
OI
in
the
first
year
after
the
diagnosis
of
pemphigus
was
9
.
3
%
,
subsequently
dropping
to
0
.
Advanced
age
and
possibly
diabetes
were
found
to
be
risk
factors
for
OI
development
.
Infectious
agents
included
Nocardia
,
cytomegalovirus
,
Legionella
,
and
Listeria
.
Two
patients
died
within
2
months
of
OI
diagnosis
,
and
2
more
had
neurologic
impairment
.
Limitations
include
the
extraction
of
historical
data
and
the
cohort
originating
from
a
single
geographic
region
.
O
Is
present
in
a
significant
number
of
patients
with
pemphigus
during
the
first
year
after
the
diagnosis
of
pemphigus
,
with
potential
deleterious
effects
.
Older
and
possibly
diabetic
patients
are
at
increased
risk
.
Physician
vigilance
and
patient
education
on
limiting
pathogen
exposure
is
recommended
.
