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Patients' age and the dynamics of IgM for L. pneumophila sg1.
[legionellosis]
The
results
of
IgM
L
.
pneumophila
sg
1
test
in
304
adults
and
270
children
performed
at
NIPH-NIH
in
2004
-
2007
were
analyzed
to
determine
the
effects
of
patients
'
age
and
the
interval
between
collected
sera
on
the
results
and
the
interpretation
.
Significant
difference
in
the
level
of
IgM
,
depending
on
the
age
of
the
patients
(
P
0
=
0
.
0084
)
was
found
.
Positive
results
(
in
total
20
.
4
%
of
patients
)
were
the
most
frequently
observed
in
patients
aged
19
-
29
years
(
42
.
5
%
)
,
and
the
least--
in
patients
60
y
.
o
.
and
<
2
y
.
o
.
(
7
%
)
.
Average
and
median
levels
of
IgM
in
these
two
groups
(
+
60
y
.
o
.
and
<
2
y
.
o
.
)
were
similar
and
significantly
different
from
the
results
in
the
other
groups
.
From
44
adults
and
33
children
>
or
=
2
sera
were
collected
.
There
was
a
significant
difference
in
the
interval
between
collecting
the
first
and
second
serum
sample
in
adults
(
mainly
3
-
5
weeks
)
and
children
(
mainly
2
-
4
weeks
)
.
Significant
increase
of
IgM
levels
was
observed
in
children
when
the
interval
between
1
and
2
sample
did
n't
exceed
4
weeks
,
while
in
adults
this
change
was
also
observed
at
>
5
weeks
(
25
%
of
patients
)
.
No
significant
differences
in
the
analysis
of
the
IgM
ratio
in
children
(
1
.
25
-
14
)
and
adults
(
1
.
5
-
26
)
was
found
,
but
longer
persistence
of
IgM
in
adults
than
in
children
was
observed
.
Demonstrated
trend
of
faster
decline
in
the
level
of
IgM
among
children
than
in
adults
indicated
that
in
suspected
case
of
legionellosis
in
children
,
the
serum
sample
should
be
taken
up
to
4
-
5
weeks
after
the
onset
,
and
at
intervals
of
1
-
2
weeks
maximum
.
Diseases
Validation
Diseases presenting
"while in adults this change"
symptom
legionellosis
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