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Physiological skin manifestations in twins: association with maternal and neonatal factors.
[lamellar ichthyosis]
There
is
paucity
of
literature
on
the
incidence
and
clinical
associations
of
transient
benign
dermatological
conditions
in
twin
neonates
.
This
prospective
study
evaluated
253
live-born
twin
babies
(
≥
23
wks
)
at
a
tertiary
care
hospital
in
Delhi
,
India
.
All
study
subjects
were
observed
for
the
first
7
days
of
life
,
and
regular
dermatological
examination
was
performed
.
The
primary
focus
was
on
palatine
Epstein
pearls
(
PEP
)
,
milia
,
erythema
toxicum
neonatorum
(
ETN
)
,
and
physiological
skin
desquamation
(
PDS
)
.
Zygosity
was
determined
with
the
help
of
sex
combination
of
the
pairs
,
chorionicity
of
the
placentae
,
and
seven
blood
group
phenotypes
.
Chi
-square
test
,
Cohen
's
kappa
test
,
and
logistic
regression
analysis
were
done
.
PEP
,
milia
,
ETN
,
and
PDS
were
seen
in
88
.
1
%
,
83
.
4
%
,
2
.
4
%
,
and
4
.
3
%
twin
babies
,
respectively
.
Preputial
Epstein
pearls
were
not
seen
.
Birth
order
,
maternal
anemia
,
route
of
delivery
,
meconium
staining
of
amniotic
fluid
,
gestational
maturity
,
birth
weight
,
and
presence
of
intrauterine
growth
restriction
were
found
to
be
associated
with
one
or
more
of
the
studied
skin
conditions
(
p
<
0
.
05
)
,
but
maternal
age
,
pregnancy-induced
hypertension
,
and
sex
of
the
baby
did
not
affect
incidence
of
any
(
p
>
0
.
05
)
.
The
intrapair
concordance
was
highly
significant
(
p
<
0
.
001
)
in
mono-
and
dizygotic
twins
.
PEP
and
milia
were
equally
common
in
the
evaluated
twins
as
compared
to
reports
in
singletons
,
while
ETN
and
PDS
were
less
common
in
this
twin
cohort
.
Environmental
and
genetic
factors
may
regulate
physiological
skin
manifestations
in
newborns
.
Diseases
Validation
Diseases presenting
"while etn and pds were less common in this twin cohort"
symptom
lamellar ichthyosis
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