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Successful treatment with topical N-acetylcysteine in urea in five children with congenital lamellar ichthyosis.
[lamellar ichthyosis]
We
reported
the
efficacy
of
topical
cutaneous
N-
acetylcysteine
in
children
with
type
I
lamellar
ichthyosis
.
The
drug
was
applied
on
predetermined
body
surface
areas
two
times
a
day
for
6
weeks
,
followed
by
a
daily
maintenance
application
.
During
the
first
2
weeks
of
treatment
,
a
significant
improvement
occurred
.
After
4
months
of
maintenance
application
,
a
marked
overall
improvement
occurred
in
all
the
treated
areas
.
Only
two
patients
showed
mild
adverse
effects
such
as
light
burning
,
pruritus
,
and
irritation
.
Even
though
a
larger
group
of
patients
should
be
necessary
to
confirm
the
data
,
topical
10
%
N-
acetylcysteine
emulsion
prepared
in
urea
5
%
seems
to
be
a
valuable
and
safe
therapeutic
option
for
lamellar
ichthyosis
in
children
,
with
benefit
not
only
for
skin
lesions
but
also
for
ectropion
avoiding
a
surgical
procedure
.
Diseases
Validation
Diseases presenting
"and irritation"
symptom
lamellar ichthyosis
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