Rare Diseases Symptoms Automatic Extraction
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A random Abstract
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Development of a disease severity score for newborns with collodion membrane.
[lamellar ichthyosis]
Collodion
membrane
in
the
neonate
may
be
the
initial
presentation
of
a
number
of
different
conditions
.
There
is
a
lack
of
data
correlating
the
extent
of
clinical
involvement
to
the
underlying
disease
and
prognosis
.
We
sought
to
identify
features
predictive
of
the
final
outcome
and
complications
in
a
cohort
of
patients
with
collodion
membrane
,
using
a
disease
severity
score
.
This
was
a
retrospective
cohort
study
of
newborns
with
collodion
membrane
at
a
tertiary
care
institution
over
a
period
of
31
years
.
We
designed
and
applied
a
0
-
to
15
-
point
severity
score
and
correlated
the
results
with
the
final
diagnoses
and
complications
.
Data
on
demographics
,
membrane
shedding
,
and
treatment
were
collected
.
We
identified
29
cases
.
Congenital
ichthyosiform
erythroderma
and
lamellar
ichthyosis
were
the
most
common
final
diagnoses
with
7
of
29
cases
(
24
%
)
each
;
3
patients
were
given
the
diagnosis
of
a
syndromic
ichthyosis
.
The
classic
nonsyndromic
ichthyoses
had
higher
average
score
results
(
7
.
33
)
than
the
syndromic
ichthyoses
(
2
.
0
)
and
other
presentations
(
4
.
0
)
,
(
P
Â
=
.
0097
)
.
Patients
with
major
complications
had
higher
,
but
nonsignificant
,
average
severity
scores
(
P
Â
=
.
64
)
.
The
retrospective
design
and
small
number
of
patients
with
a
syndromic
ichthyosis
are
limitations
.
Prospective
studies
are
required
to
validate
the
proposed
disease
severity
score
.
