Peripheral neuropathy in late-onset Krabbe disease: report of three cases.

[krabbe disease]

Late -onset Krabbe disease may have variable misleading clinical manifestations and be a puzzling problem for physicians . We report clinical and peripheral nerve studies of three patients with adult-onset Krabbe disease . Two cases had a predominantly spastic paraparesis ; in one case , the symptoms mimicked a cerebrovascular disorder . Predominantly , demyelinating neuropathy was observed in one case and axonal neuropathy in two cases . In all cases , no typical intracytoplasmic inclusions were found . These observations suggest that peripheral neuropathy in adult-onset Krabbe disease has variable clinical and pathological characteristics , different from those described in the classic form .

Diseases
Validation

Diseases presenting "peripheral neuropathy" symptom

adrenomyeloneuropathy

esophageal squamous cell carcinoma

hodgkin lymphoma, classical

homocystinuria without methylmalonic aciduria

kallmann syndrome

krabbe disease

neuralgic amyotrophy

oculocutaneous albinism

pyruvate dehydrogenase deficiency

sneddon syndrome

systemic capillary leak syndrome

thoracic outlet syndrome

triple a syndrome

waldenström macroglobulinemia

x-linked adrenoleukodystrophy

zellweger syndrome

This symptom has already been validated