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Kindler syndrome in a Saudi kindred.
[kindler syndrome]
We
report
a
large
consanguineous
Saudi
-
Arabian
pedigree
containing
11
individuals
with
the
autosomal
recessive
genodermatosis
,
Kindler
syndrome
.
Three
affected
cases
died
in
infancy
but
the
remaining
eight
had
signs
of
photosensitivity
,
generalized
poikiloderma
,
webbed
fingers
,
loss
of
dermatoglyphics
and
nail
dystrophy
.
The
majority
also
had
oral
involvement
with
bleeding
gums
.
Additional
features
seen
in
some
cases
included
pseudoainhum
of
the
toes
,
sclerotic
bands
on
the
wrists
and
hand
deformities
.
The
aetiology
of
Kindler
syndrome
is
not
yet
known
,
but
the
underlying
defect
leads
to
both
cutaneous
and
oral
inflammation
,
along
with
photosensitivity
and
scarring
.
Diseases
Validation
Diseases presenting
"sclerotic bands on the wrists and hand deformities"
symptom
kindler syndrome
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