Rare Diseases Symptoms Automatic Extraction
Home
A random Abstract
Our Project
Our Team
Clinical and microbiologic study of periodontitis associated with Kindler syndrome.
[kindler syndrome]
Little
is
known
about
the
onset
and
prevalence
of
periodontal
disease
in
patients
with
the
rare
Kindler
syndrome
,
a
genodermatological
disorder
.
This
study
investigated
the
level
of
clinical
periodontal
attachment
in
relation
to
age
and
presence
of
putative
periodontopathogenic
bacteria
in
individuals
with
Kindler
syndrome
.
Eighteen
individuals
diagnosed
with
Kindler
syndrome
and
13
control
subjects
,
aged
4
to
37
years
,
from
rural
Panama
received
a
limited
clinical
periodontal
examination
.
Subgingival
samples
were
collected
for
identification
of
putative
periodontal
pathogens
by
polymerase
chain
reaction
.
Mild
to
severe
gingivitis
was
a
common
finding
in
all
adults
of
the
study
population
.
Seventy
-
two
percent
(
13
/
18
)
of
the
Kindler
patients
and
46
%
(
6
/
13
)
of
the
control
subjects
showed
mild
to
severe
periodontal
disease
(
P
=
0
.
001
,
chi
-square
test
)
.
The
onset
of
periodontitis
was
earlier
and
the
progression
occurred
at
a
faster
rate
in
the
Kindler
group
.
There
was
a
strong
correlation
(
r
=
0
.
83
)
between
the
level
of
attachment
loss
and
age
in
the
Kindler
group
and
a
weaker
correlation
(
r
=
0
.
66
)
in
the
control
group
.
The
appearance
of
gingival
tissues
suggested
atypical
periodontitis
with
spontaneous
bleeding
and
fragile
,
often
desquamative
,
gingiva
.
In
periodontitis
patients
,
Porphyromonas
gingivallis
and
Diallster
pneumosintes
tended
to
occur
more
frequently
in
control
individuals
compared
to
those
with
Kindler
syndrome
.
In
the
Kindler
group
,
periodontitis
had
an
onset
in
early
teenage
years
and
progressed
more
rapidly
compared
to
non-
Kindler
individuals
of
the
same
geographic
and
ethnic
group
.
Clinical
and
microbiological
findings
suggest
atypical
periodontitis
in
Kindler
patients
.
We
propose
to
include
Kindler
syndrome
in
the
category
of
medical
disorders
predisposing
to
destructive
periodontal
disease
.
Diseases
Validation
Diseases presenting
"periodontitis"
symptom
cohen syndrome
dentin dysplasia
kindler syndrome
papillon-lefèvre syndrome
This symptom has already been validated