Rare Diseases Symptoms Automatic Extraction
Home
A random Abstract
Our Project
Our Team
Developmental expression of the fermitin/kindlin gene family in Xenopus laevis embryos.
[kindler syndrome]
Fermitin
genes
are
highly
conserved
and
encode
cytocortex
proteins
that
mediate
integrin
signalling
.
Fermitin
1
(
Kindlin
1
)
is
implicated
in
Kindler
syndrome
,
a
human
skin
blistering
disorder
.
We
report
the
isolation
of
the
three
Fermitin
orthologs
from
Xenopus
laevis
embryos
and
describe
their
developmental
expression
patterns
.
Fermitin
1
is
expressed
in
the
skin
,
otic
and
olfactory
placodes
,
pharyngeal
arches
,
pronephric
duct
,
and
heart
.
Fermitin
2
is
restricted
to
the
somites
and
neural
crest
.
Fermitin
3
is
expressed
in
the
notochord
,
central
nervous
system
,
cement
gland
,
ventral
blood
islands
,
vitelline
veins
,
and
myeloid
cells
.
Our
findings
are
consistent
with
the
view
that
Fermitin
1
is
generally
expressed
in
the
skin
,
Fermitin
2
in
muscle
,
and
Fermitin
3
in
hematopoietic
lineages
.
Moreover
,
we
describe
novel
sites
of
Fermitin
gene
expression
that
extend
our
knowledge
of
this
family
.
Our
data
provide
a
basis
for
further
functional
analysis
of
the
Fermitin
family
in
Xenopus
laevis
.
Diseases
Validation
Diseases presenting
"developmental expression patterns"
symptom
kindler syndrome
You can validate or delete this automatically detected symptom
Validate the Symptom
Delete the Symptom